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Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 41-44 doi: 10.1007/s11684-009-0009-6

Abstract: non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLC(23 cases of lung squamous cell cancer, 16 cases of lung adenocarcinoma) and tumor-surrounding normalThe Syk expression was positively correlated withthe p53 expression in NSCLC specimens ( = 0.025).size and tumor node metastasis (TNM).

Keywords： Syk kinase     carcinoma     non-small-cell lung     tumor suppressor protein p53    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: In this study, we identified the correlation between p53 functional activation and its genotype in fiveTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayFurther, the expression of p53 protein and four transcripts of well-known p53 target genes were investigatedThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could beTo judge p53 function in a particular cell line, it is important to examine the p53 functional activation

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 1-15 doi: 10.1007/s11705-016-1562-6

Abstract: successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53

Keywords： synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutationsIn a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivityof tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: In this study, survival fraction at 2Gy (SF2) values of eight human tumor cell lines (including fourWe found that the expression of same protein in different cell lines and the expression of three proteinsThe SF2 values were also different in eight tumor cell lines and there was a positive correlativity betweenThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predictingthe radiosensitivity of tumor cells.

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 374-386 doi: 10.1007/s11684-018-0652-x

Abstract: <p>A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiationOn the contrary, certain Id proteins are reported to act as tumor suppressors in the development of BurkittThe contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumorWe re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor developmentp>

Keywords： Id proteins     lymphoma     leukemia     T cells     B cells     tumor suppressor     oncogene    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor gene

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasThe aim of the study is to investigate the extracellular regulated protein kinases (ERKs) pathway ofHBx on glomerular mesangial cell (GMC) proliferation and tumor necrosis factor-α (TNF-α) expressionHBx, ERK and p-ERK expression in GMCs was assessed by Western blotting.can conclude that HBx could induce GMC proliferation and increase TNF-α mRNA expression and its protein

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellite

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR)     gastrointestinal tumor     hypermutability    

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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: during tumorigenesis, and expression levels are inversely correlated with the malignant phenotype of tumorcells, validating that is a real tumor suppressor gene.Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, encodesHere, we briefly review the latest discoveries on Ecrg4 and its underlying molecular mechanisms as a tumorsuppressor and focus on the emerging roles of Ecrg4 in the CVS.

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cellWestern blot was performed to detect the phosphorylation of p38 in NIH3T3 cells treated with PDGF.the migration of NIH3T3 cells and the influence of deficiency on this process in a gene knockout (p38Furthermore, the PDGF-induced cell migration was significantly blocked in gene knockout (p38) mouseembryonic fibroblasts (MEFs) (〈0.001) as compared with the wild type cells (p38). p38 MAPK plays an important

Keywords： control     stimulation     mitogen-activated     growth factor     process    

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 232-237 doi: 10.1007/s11705-012-1286-1

Abstract: Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK (mitogenactivated protein kinase) SB 203580 and JNK inhibitor SP 600125, and a control.Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascadesSB203580 inhibits the expression of p38, c-Jun and c-Fos.When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38

Keywords： connective tissue     mitogen activated protein kinase (MAPK)     p38     JNK    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: <p>Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide.In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressedapproximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (PP&p>

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: We cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, andEctopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymousSNP     GPI-anchored protein    

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Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 73-83 doi: 10.15302/J-FASE-2015044

Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein can inhibit the signal transduction triggered by someis predicted to encode a 207-amino acid protein, which shares high amino acid sequence identity (64%–Chicken is predicted to encode a 212-amino acid protein, which shares only 30%–32% amino acid sequence

Keywords： chicken     SOCS1a     SOCS1b     growth hormone     prolactin    

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Title Author Date Type Operation

Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters

Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivityof tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells

Sumedha Roy, Yuan Zhuang

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

Irina A SHURYGINA, Michael G SHURYGIN, Nataliya I AYUSHINOVA, Galina B GRANINA, Nikolay V ZELENIN

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

Journal Article

Molecular characterization of two suppressor of cytokine signaling 1 genes (

Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG

Journal Article